Major+questions


 * **Why is genotype-dosing warfarin cost-effectiveness study important?**

Baseline performance in INR control of standard AC care CYP2C9, VKORC1 Patient clinical characteristics and genotypes of CYP2C9 and VKORC1 accounts as much as 60% (YouEtal2009 16-18)
 * **What are the key factors that influence the effect of warfarin therapy?**
 * **What are the enzymes that are responsible for metabolic clearance of warfarin?**
 * **What explain the variability of warfarin dose requirement?**
 * **What are the existing warfarin dosing algorithms used in clinical trials?**

Adverse event rate, survival rate and QALYs (YouEtal2009)
 * **What are the existing assessment of genotype-guided warfarin dosing effectiveness?**
 * **What is the transferability of economic evaluation results between countries?** [|**Welte et al**]


 * **How to use sensitivity test to examine the robustness of the results derived from literatures and clinical trials which might contain certain degree of uncertainty?**